And people researching areas such as satiety (the satisfied feeling of being full after eating) have been working on gut-brain signalling for hundreds of years already. Nonetheless, Hippocrates already stated: “All disease begins in the gut”. The work that we do now, which is looking at signals between the gut and the brain, disrupts that, and people may think it is totally new. John Cryan: As I work in the neuroscience department of a medical school, I know from experience that in medicine we tend to compartmentalise the body neuroscientists are trained to predominantly focus on what happens above the neck. Your work gravitates around the interaction between the brain, gut and microbiome (the microorganisms in a particular environment). According to his groundbreaking work, the gut influences our brain including stress and our emotions. He is the principal investigator in the APC Microbiome Ireland research institute and a member of the Federation of European Neuroscience Societies. “Understanding how our brain is constantly receiving signals through our gut, as well as the microbiome living there, is of great importance for all aspects of our physiology”, says Irish neuroscientist Professor John Cryan.
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